THE PRO- AND ANTI-INFLAMMATORY CYTOKINES CONTENTS IN MICE AFTER STAPHYLOCOCCUS AUREUS BACTERIOPHAGE ADMINISTRAT

Abstract

А contents of the proinflammatory – TNF-α, γ-IFN; and anti-inflammatory – IL 10 cytokines in mice after one- and three times administration of the Staphylococcus aureus bacteriophage have been studied. Results of this investigation show that even one administration of this preparation, posses a strong changes in the level of the examined cytokines. γ-IFN content in serum, lymph nodes and spleen of mice increase in 2.2–2.9 times, and content of the TNF-α increase for 20–28%. After three times administration of the Staphylococcus aureus bacteriophage, level of this cytokines increase were higher, then after one time injection, especial for γ-IFN. Its level in serum and lymphoid organs was in 8–10 times higher in contrast the control animals. Tumor necrosis factor content increased for 50–60%. In contrast, level of the IL 10 were decrease and after three time administration of this preparation its level compiled a half over there starting level.

Keywords

• бактеріофаг staphylococcus aureus
• вміст про- і протизапальних цитокінів
• фактор некрозу пухлин альфа (фнп-α)
• гамма інтерферон (γ-iфн)
• інтерлейкін10 (iл 10)