Design of a Helical-Stabilized, Cyclic, and Nontoxic Analogue of the Peptide Cm-p5 with Improved Antifungal Activity

• Fidel E. Morales Vicente,
• Melaine González-Garcia,
• Erbio Diaz Pico,
• Elena Moreno-Castillo,
• Hilda E. Garay,
• Pablo E. Rosi,
• Asiel Mena Jimenez,
• Jose A. Campos-Delgado,
• Daniel G. Rivera,
• Glay Chinea,
• Rosemeire C. L. R. Pietro,
• Steffen Stenger,
• Barbara Spellerberg,
• Dennis Kubiczek,
• Nicholas Bodenberger,
• Steffen Dietz,
• Frank Rosenau,
• Márcio Weber Paixão,
• Ludger Ständker,
• Anselmo J. Otero-González

Affiliations

Fidel E. Morales Vicente

†General Chemistry Department, Faculty of Chemistry, University of Havana, La Habana, Cuba

Melaine González-Garcia

Center for Protein Studies, Faculty of Biology, University of Havana, La Habana, Cuba

Erbio Diaz Pico

Synthetic Peptides Group, Center for Genetic Engineering and Biotechnology, La Habana, Cuba

Elena Moreno-Castillo

‡Center for Natural Products Research, Faculty of Chemistry, University of Havana, La Habana, Cuba

Hilda E. Garay

Synthetic Peptides Group, Center for Genetic Engineering and Biotechnology, La Habana, Cuba

Pablo E. Rosi

Department of Inorganic Chemistry, Analytical and Physical Chemistry, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina

Asiel Mena Jimenez

‡Center for Natural Products Research, Faculty of Chemistry, University of Havana, La Habana, Cuba

Jose A. Campos-Delgado

Center of Excellence for Research in Sustainable Chemistry (CERSusChem), Department of Chemistry, Federal University of São Carlos-UFSCar, São Paulo, Brazil

Daniel G. Rivera

‡Center for Natural Products Research, Faculty of Chemistry, University of Havana, La Habana, Cuba

Glay Chinea

Synthetic Peptides Group, Center for Genetic Engineering and Biotechnology, La Habana, Cuba

Rosemeire C. L. R. Pietro

Laboratory of Pharmaceutical Biotechnology, Department of Drugs and Medicines, School of Pharmaceutical Sciences, UNESP, Araraquara, Brazil

Steffen Stenger

Institute of Medical Microbiology and Hygiene, University Clinic of Ulm, Ulm, Germany

Barbara Spellerberg

Institute of Medical Microbiology and Hygiene, University Clinic of Ulm, Ulm, Germany

Dennis Kubiczek

Institute of Pharmaceutical Biotechnology, Ulm University, Ulm, Germany

Nicholas Bodenberger

Institute of Pharmaceutical Biotechnology, Ulm University, Ulm, Germany

Steffen Dietz

Institute of Pharmaceutical Biotechnology, Ulm University, Ulm, Germany

Frank Rosenau

Institute of Pharmaceutical Biotechnology, Ulm University, Ulm, Germany

Márcio Weber Paixão

Center of Excellence for Research in Sustainable Chemistry (CERSusChem), Department of Chemistry, Federal University of São Carlos-UFSCar, São Paulo, Brazil

Ludger Ständker

Core Facility for Functional Peptidomics, Ulm Peptide Pharmaceuticals (U-PEP), University Ulm, Faculty of Medicine, Ulm University, Ulm, Germany

Anselmo J. Otero-González

Center for Protein Studies, Faculty of Biology, University of Havana, La Habana, Cuba