EXAMINATION OF THE LIPID PROFILE IN PREGNANT OBESE WOMEN, CONSIDERING THE ALLELE STATUS OF THE GENES OF ANGIOTENSIN-CONVERTING ENZYME (ACE I / D) AND PLASMINOGEN-1 (PA-1 4G / 5G) ACTIVATOR-INHIBITOR

Abstract

Changes in the lipid profile in pregnant women, with and without obesity, have been studied depending on the angiotensin-converting enzyme (ACE) gene I/ D polymorphism and the 4G5G polymorphism of the plasminogen activator inhibitor type I (PAI-1). The combination of the D-allele of the ACE gene and the 5G allele of the PAI-1 gene is a risk factor of increasing total cholesterol in pregnant women, regardless of the obesity class, and of increasing triglycerides in pregnant women without obesity. The presence of the D-allele of the ACE gene in the haplotype, regardless of the combinations of the genotypes of the PAI-1 gene, is a risk factor of increasing triglycerides in pregnant women with obesity.

Keywords

• pregnancy
• obesity
• lipids
• ACE gene polymorphism
• PAI-1gene polymorphism