Nature Communications (Nov 2018)

A third generation of radical fluorinating agents based on N-fluoro-N-arylsulfonamides

  • Daniel Meyer,
  • Harish Jangra,
  • Fabian Walther,
  • Hendrik Zipse,
  • Philippe Renaud

DOI
https://doi.org/10.1038/s41467-018-07196-9
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

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Common radical fluorination reagents, such as Selectofluor®, are penalized by the need for metal catalysts and possible oxidation side reactions. Here, the authors reported the synthesis and application of N-fluoro-N-arylsulfonamides (NFASs) as third generation of radical fluorinating reagents to overcome those limitations.