Nature Communications (Jun 2018)

A microfluidics platform for combinatorial drug screening on cancer biopsies

  • Federica Eduati,
  • Ramesh Utharala,
  • Dharanija Madhavan,
  • Ulf Peter Neumann,
  • Thomas Longerich,
  • Thorsten Cramer,
  • Julio Saez-Rodriguez,
  • Christoph A. Merten

DOI
https://doi.org/10.1038/s41467-018-04919-w
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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Cancer patients exhibit specific sensitivities toward drug combinations that cannot be easily predicted. Here the authors setup a microfluidic platform that allows testing of multiple drug combinations correctly predicting sensitivity in vivo and they use it on patients biopsies to define effective drugs.