Preclinical Assessment Addressing Intravenous Administration of a [<sup>68</sup>Ga]Ga-PSMA-617 Microemulsion: Acute In Vivo Toxicity, Tolerability, PET Imaging, and Biodistribution
Vusani Mandiwana,
Lonji Kalombo,
Rose Hayeshi,
Jan Rijn Zeevaart,
Thomas Ebenhan
Affiliations
Vusani Mandiwana
Centre for Nanostructures and Advanced Materials CeNAM, Chemical Cluster, Advanced Functional Materials, Council for Scientific and Industrial Research, Pretoria 0001, South Africa
Lonji Kalombo
Centre for Nanostructures and Advanced Materials CeNAM, Chemical Cluster, Advanced Functional Materials, Council for Scientific and Industrial Research, Pretoria 0001, South Africa
Rose Hayeshi
Department of Science and Technology, Preclinical Drug Development Platform, North West University, Potchefstroom 2520, South Africa
Jan Rijn Zeevaart
Department of Science and Technology, Preclinical Drug Development Platform, North West University, Potchefstroom 2520, South Africa
Thomas Ebenhan
Department of Science and Technology, Preclinical Drug Development Platform, North West University, Potchefstroom 2520, South Africa
It has been herein presented that a microemulsion, known to be an effective and safe drug delivery system following intravenous administration, can be loaded with traces of [68Ga]Ga-PSMA-617 without losing its properties or causing toxicity. Following tolerated IV injections the capability of the microemulsion in altering [68Ga]Ga-PSMA-617 distribution was presented at 120 min post injection based on its ex vivo biodistribution results.
