Palladium-catalysed formation of vicinal all-carbon quaternary centres via propargylation

Xin Huang; Shangze Wu; Wangteng Wu; Pengbin Li; Chunling Fu; Shengming Ma

doi:10.1038/ncomms12382

Nature Communications (Aug 2016)

Palladium-catalysed formation of vicinal all-carbon quaternary centres via propargylation

Xin Huang,
Shangze Wu,
Wangteng Wu,
Pengbin Li,
Chunling Fu,
Shengming Ma

Affiliations

Xin Huang: Department of Chemistry, Laboratory of Molecular Recognition and Synthesis, Zhejiang University
Shangze Wu: Department of Chemistry, Laboratory of Molecular Recognition and Synthesis, Zhejiang University
Wangteng Wu: Department of Chemistry, Laboratory of Molecular Recognition and Synthesis, Zhejiang University
Pengbin Li: Department of Chemistry, Laboratory of Molecular Recognition and Synthesis, Zhejiang University
Chunling Fu: Department of Chemistry, Laboratory of Molecular Recognition and Synthesis, Zhejiang University
Shengming Ma: Department of Chemistry, Laboratory of Molecular Recognition and Synthesis, Zhejiang University

DOI: https://doi.org/10.1038/ncomms12382
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 8

Abstract

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Formation of vicinal, quaternary stereocentres is challenging, but such products are commonly encountered in nature. Here, the authors report a palladium catalysed process to form vicinal quaternary carbons via propargylation, including in enantiopure form when optically active starting materials are employed.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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