Nature Communications (Nov 2017)
An unexpected protein interaction promotes drug resistance in leukemia
- Aaron Pitre,
- Yubin Ge,
- Wenwei Lin,
- Yao Wang,
- Yu Fukuda,
- Jamshid Temirov,
- Aaron H. Phillips,
- Jennifer L. Peters,
- Yiping Fan,
- Jing Ma,
- Amanda Nourse,
- Chandrima Sinha,
- Hai Lin,
- Richard Kriwacki,
- James R. Downing,
- Tanja A. Gruber,
- Victoria E. Centonze,
- Anjaparavanda P. Naren,
- Taosheng Chen,
- John D. Schuetz
Affiliations
- Aaron Pitre
- Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital (SJCRH)
- Yubin Ge
- Department of Oncology and the Molecular Therapeutics Program of the Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine
- Wenwei Lin
- Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital (SJCRH)
- Yao Wang
- Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital (SJCRH)
- Yu Fukuda
- Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital (SJCRH)
- Jamshid Temirov
- Cell and Tissue Imaging Center, St. Jude Children’s Research Hospital (SJCRH)
- Aaron H. Phillips
- Department of Structural Biology, St. Jude Children’s Research Hospital (SJCRH)
- Jennifer L. Peters
- Cell and Tissue Imaging Center, St. Jude Children’s Research Hospital (SJCRH)
- Yiping Fan
- Department of Computational Biology, St. Jude Children’s Research Hospital (SJCRH)
- Jing Ma
- Department of Pathology, St. Jude Children’s Research Hospital (SJCRH)
- Amanda Nourse
- Molecular Interaction Analysis Shared Resource, St. Jude Children’s Research Hospital (SJCRH)
- Chandrima Sinha
- Department of Physiology, University of Tennessee Health Sciences Center
- Hai Lin
- Department of Hematology and Oncology, The First Hospital of Jilin University
- Richard Kriwacki
- Department of Structural Biology, St. Jude Children’s Research Hospital (SJCRH)
- James R. Downing
- Department of Pathology, St. Jude Children’s Research Hospital (SJCRH)
- Tanja A. Gruber
- Department of Pathology, St. Jude Children’s Research Hospital (SJCRH)
- Victoria E. Centonze
- Cell and Tissue Imaging Center, St. Jude Children’s Research Hospital (SJCRH)
- Anjaparavanda P. Naren
- Division of Pulmonary Medicine, Cincinnati Children’s Hospital Medical Center
- Taosheng Chen
- Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital (SJCRH)
- John D. Schuetz
- Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital (SJCRH)
- DOI
- https://doi.org/10.1038/s41467-017-01678-y
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
ABCC4 is a chemotherapeutic drug exporter highly expressed in acute myeloid leukemia. Here, the authors demonstrate that MPP1 anchors ABCC4 to the outer cell membrane mediating drug resistance in leukemic cells and identify antimycin A as a chemical probe that disrupts such interaction and restores sensitivity.
