Delayed cord clamping for prevention of iron deficiency anemia in term infants

Abstract

Background Iron deficiency childhood is a concern due to its potentially detrimental effects on development, some of which may be irreversible even after iron treatment. Delayed cord clamping may prevent IDA by increasing an infant's iron reserve at birth. Objective We aimed to evaluate the effect of delayed umbilical cord clamping at birth on the iron status in newborns at age 24 hours of life. Methods This randomized, single􀁒blind study was conducted from March to May 2009, at two general hospitals in Medan, North Sumatera Province. Eligible newborn infants were randomly assigned to one of two groups: early cord clamping (Eee) performed 15 seconds after delivery or delayed cord clamping (DeC) performed 2 minutes after delivery. Infants were placed on their mothers' abdomens before the umbilical cords were clamped. Hematologic status was determined from umbilical cord blood. Results Sixty􀁒three subjects were included in our study, consisting of31 infants in the Eee group and 32 infants in the Dec group. We found that mean neonatal hemoglobin level was higher in the Dec group than in the Eee group ( 18.4 g% and 16.2 g%, respectively, P=O.OOOl). Also, mean ferritin level was higher in the Dec group than in the Eee group (556 mg/dL and 329 mg/ dL, respectively, p=o.o 15). Other hematological status indicators, including mean hematocrit and mean corpuscular volume (MeV) level, were also higher in the Dec group. However, mean red blood cell levels were not significantly groups. Nor was there a significant level between the Dec and Eee groups. Concl usion Dela y ed cord c l a m p i n g m a y improve iron status and prevent IDA in term infants. [Paediatr Indones. 2012;52:223-8].

Keywords

• delayed cord clamping
• iron deficiency anemia
• term infants