The change in function of Th1 and Th2-lymphocytes and cytokine profile at chronic intoxication of ethanol

Abstract

In experiments in non-inbred rats, it has been established that chronic intoxication of ethanol (30 days, total dose – 6.0 LD50) essentially reduces concentration of cytokines IFNγ, IL-2, IL-4, IL-10 in blood, increases concentration of IL-6, reduces an interrelation IFNγ/IL-4 in comparison with the control, suppresses of immune responses, which displays the greater lesion of Th1-cells in comparison with Th2-lymphosytes.

Keywords

• ethanol
• immunotoxity
• cytokines
• Тh1
• Th2
• lymphosytes