Effects of Moderate Treadmill Exercise on Anxiety and Serum Corticosterone and IGF-1 Levels in A Rat Model of Post-Traumatic Stress Disorder

Abstract

Background and purpose: Post-traumatic stress disorder (PTSD (is a psychotic illness caused by different types of stressors and is associated with high economic and psychological burdens on health systems. Physiological studies of the brain have shown that serum corticosterone and insulin-like growth factor 1 (IGF-1) levels have important roles during brain damage and trauma to the nervous system. In this project, we studied the effect of exercise as an effective factor on improving anxiety and serum levels of corticosterone and IGF-1in male PTSD rats. Materials and methods: In this experimental study, single prolonged stress (SPS) was used to induce PTSD in male Wistar rats. The animals were divided into two groups: Sham (Non-SPS [NSPS]) and SPS. The two groups were then divided into two subgroups and one of the subgroups in each group did the exercise after two weeks which continued for four weeks according to the following program: moderate treadmill exercise, 5 days a week; the first two weeks 10m/min and the second two weeks 15m/min). Then, anxiety test was performed by open field test and serum levels of IGF-1 and corticosterone were measured using Eliza. Results: The rats in SPS group exhibited increased anxiety levels in open field test, decreased serum IGF-1 levels, and increased serum corticosterone levels compared with the controls. Moderate treadmill exercise alleviated SPS-induced alterations, anxiety, and IGF-1 and corticosterone levels. Conclusion: Moderate exercise could be used as a useful complementary treatment in behavioral and molecular injuries in PTSD patients.

Keywords

• ptsd
• single prolonged stress
• moderate exercise
• anxiety
• igf-1
• corticosterone