Nature Communications (Jun 2018)
Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors
- César López-Camacho,
- Peter Abbink,
- Rafael A. Larocca,
- Wanwisa Dejnirattisai,
- Michael Boyd,
- Alex Badamchi-Zadeh,
- Zoë R. Wallace,
- Jennifer Doig,
- Ricardo Sanchez Velazquez,
- Roberto Dias Lins Neto,
- Danilo F. Coelho,
- Young Chan Kim,
- Claire L. Donald,
- Ania Owsianka,
- Giuditta De Lorenzo,
- Alain Kohl,
- Sarah C. Gilbert,
- Lucy Dorrell,
- Juthathip Mongkolsapaya,
- Arvind H. Patel,
- Gavin R. Screaton,
- Dan H. Barouch,
- Adrian V. S. Hill,
- Arturo Reyes-Sandoval
Affiliations
- César López-Camacho
- The Jenner Institute, Nuffield Department of Medicine, University of Oxford, The Henry Wellcome Building for Molecular Physiology
- Peter Abbink
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- Rafael A. Larocca
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- Wanwisa Dejnirattisai
- Division of Immunology and Inflammation, Department of Medicine, Hammersmith Campus, Imperial College London
- Michael Boyd
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- Alex Badamchi-Zadeh
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- Zoë R. Wallace
- Nuffield Department of Medicine and Oxford NIHR Biomedical Research Centre, University of Oxford
- Jennifer Doig
- MRC-University of Glasgow Centre for Virus Research, University of Glasgow
- Ricardo Sanchez Velazquez
- MRC-University of Glasgow Centre for Virus Research, University of Glasgow
- Roberto Dias Lins Neto
- Aggeu Magalhães Institute, Oswaldo Cruz Foundation
- Danilo F. Coelho
- Aggeu Magalhães Institute, Oswaldo Cruz Foundation
- Young Chan Kim
- The Jenner Institute, Nuffield Department of Medicine, University of Oxford, The Henry Wellcome Building for Molecular Physiology
- Claire L. Donald
- MRC-University of Glasgow Centre for Virus Research, University of Glasgow
- Ania Owsianka
- MRC-University of Glasgow Centre for Virus Research, University of Glasgow
- Giuditta De Lorenzo
- MRC-University of Glasgow Centre for Virus Research, University of Glasgow
- Alain Kohl
- MRC-University of Glasgow Centre for Virus Research, University of Glasgow
- Sarah C. Gilbert
- The Jenner Institute, Nuffield Department of Medicine, University of Oxford
- Lucy Dorrell
- Nuffield Department of Medicine and Oxford NIHR Biomedical Research Centre, University of Oxford
- Juthathip Mongkolsapaya
- Division of Immunology and Inflammation, Department of Medicine, Hammersmith Campus, Imperial College London
- Arvind H. Patel
- MRC-University of Glasgow Centre for Virus Research, University of Glasgow
- Gavin R. Screaton
- Division of Medical Sciences, John Radcliffe Hospital, University of Oxford
- Dan H. Barouch
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- Adrian V. S. Hill
- The Jenner Institute, Nuffield Department of Medicine, University of Oxford
- Arturo Reyes-Sandoval
- The Jenner Institute, Nuffield Department of Medicine, University of Oxford, The Henry Wellcome Building for Molecular Physiology
- DOI
- https://doi.org/10.1038/s41467-018-04859-5
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
Zika virus (ZIKV) is an emerging global health issue, but currently no licensed vaccine achieves lasting protective immunity. Here the authors show that a ZIKV vaccine containing the envelop protein without the transmembrane domain and the precursor membrane protein can provide effective protection in mouse models.
