Nature Communications (Dec 2022)
Primary exposure to SARS-CoV-2 variants elicits convergent epitope specificities, immunoglobulin V gene usage and public B cell clones
- Noemia S. Lima,
- Maryam Musayev,
- Timothy S. Johnston,
- Danielle A. Wagner,
- Amy R. Henry,
- Lingshu Wang,
- Eun Sung Yang,
- Yi Zhang,
- Kevina Birungi,
- Walker P. Black,
- Sijy O’Dell,
- Stephen D. Schmidt,
- Damee Moon,
- Cynthia G. Lorang,
- Bingchun Zhao,
- Man Chen,
- Kristin L. Boswell,
- Jesmine Roberts-Torres,
- Rachel L. Davis,
- Lowrey Peyton,
- Sandeep R. Narpala,
- Sarah O’Connell,
- Leonid Serebryannyy,
- Jennifer Wang,
- Alexander Schrager,
- Chloe Adrienna Talana,
- Geoffrey Shimberg,
- Kwanyee Leung,
- Wei Shi,
- Rawan Khashab,
- Asaf Biber,
- Tal Zilberman,
- Joshua Rhein,
- Sara Vetter,
- Afeefa Ahmed,
- Laura Novik,
- Alicia Widge,
- Ingelise Gordon,
- Mercy Guech,
- I-Ting Teng,
- Emily Phung,
- Tracy J. Ruckwardt,
- Amarendra Pegu,
- John Misasi,
- Nicole A. Doria-Rose,
- Martin Gaudinski,
- Richard A. Koup,
- Peter D. Kwong,
- Adrian B. McDermott,
- Sharon Amit,
- Timothy W. Schacker,
- Itzchak Levy,
- John R. Mascola,
- Nancy J. Sullivan,
- Chaim A. Schramm,
- Daniel C. Douek
Affiliations
- Noemia S. Lima
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Maryam Musayev
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Timothy S. Johnston
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Danielle A. Wagner
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Amy R. Henry
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Lingshu Wang
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Eun Sung Yang
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Yi Zhang
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Kevina Birungi
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Walker P. Black
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Sijy O’Dell
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Stephen D. Schmidt
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Damee Moon
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Cynthia G. Lorang
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Bingchun Zhao
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Man Chen
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Kristin L. Boswell
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Jesmine Roberts-Torres
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Rachel L. Davis
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Lowrey Peyton
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Sandeep R. Narpala
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Sarah O’Connell
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Leonid Serebryannyy
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Jennifer Wang
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Alexander Schrager
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Chloe Adrienna Talana
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Geoffrey Shimberg
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Kwanyee Leung
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Wei Shi
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Rawan Khashab
- Infectious Disease Unit, Sheba Medical Center
- Asaf Biber
- Infectious Disease Unit, Sheba Medical Center
- Tal Zilberman
- Infectious Disease Unit, Sheba Medical Center
- Joshua Rhein
- Department of Medicine, University of Minnesota Medical School
- Sara Vetter
- Minnesota Department of Health
- Afeefa Ahmed
- Department of Medicine, University of Minnesota Medical School
- Laura Novik
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Alicia Widge
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Ingelise Gordon
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Mercy Guech
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- I-Ting Teng
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Emily Phung
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Tracy J. Ruckwardt
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Amarendra Pegu
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- John Misasi
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Nicole A. Doria-Rose
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Martin Gaudinski
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Richard A. Koup
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Peter D. Kwong
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Adrian B. McDermott
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Sharon Amit
- Clinical Microbiology, Sheba Medical Center
- Timothy W. Schacker
- Department of Medicine, University of Minnesota Medical School
- Itzchak Levy
- Infectious Disease Unit, Sheba Medical Center
- John R. Mascola
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Nancy J. Sullivan
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Chaim A. Schramm
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Daniel C. Douek
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- DOI
- https://doi.org/10.1038/s41467-022-35456-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Vaccines against the WA1 SARS-CoV2 strain confer protection against other variants. However, the mechanisms underlying cross-protection are not fully understood. Here, the authors develop a method for rapid analysis of single B cells from patient samples and show that infection with a variant elicits convergent, public B cell responses to other variants.
