Actomyosin contractility-dependent matrix stretch and recoil induces rapid cell migration

William Y. Wang; Christopher D. Davidson; Daphne Lin; Brendon M. Baker

doi:10.1038/s41467-019-09121-0

Nature Communications (Mar 2019)

Actomyosin contractility-dependent matrix stretch and recoil induces rapid cell migration

William Y. Wang,
Christopher D. Davidson,
Daphne Lin,
Brendon M. Baker

Affiliations

William Y. Wang: Department of Biomedical Engineering, University of Michigan
Christopher D. Davidson: Department of Biomedical Engineering, University of Michigan
Daphne Lin: Department of Biomedical Engineering, University of Michigan
Brendon M. Baker: Department of Biomedical Engineering, University of Michigan

DOI: https://doi.org/10.1038/s41467-019-09121-0
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

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How cells migrate in fibrous tissues is still poorly understood. Here, with synthetic 3D fibre matrices of controlled alignment and stiffness, the authors report that cells in stiff matrices move slowly and continuously, but in softer, deformable matrices cells can rapidly slingshot forward via stretch and recoil of matrix fibres.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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