DNA methylation aging and transcriptomic studies in horses

Steve Horvath; Amin Haghani; Sichong Peng; Erin N. Hales; Joseph A. Zoller; Ken Raj; Brenda Larison; Todd R. Robeck; Jessica L. Petersen; Rebecca R. Bellone; Carrie J. Finno

doi:10.1038/s41467-021-27754-y

Nature Communications (Jan 2022)

DNA methylation aging and transcriptomic studies in horses

Steve Horvath,
Amin Haghani,
Sichong Peng,
Erin N. Hales,
Joseph A. Zoller,
Ken Raj,
Brenda Larison,
Todd R. Robeck,
Jessica L. Petersen,
Rebecca R. Bellone,
Carrie J. Finno

Affiliations

Steve Horvath: Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles
Amin Haghani: Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles
Sichong Peng: Department of Population Health and Reproduction, University of California, Davis School of Veterinary Medicine
Erin N. Hales: Department of Population Health and Reproduction, University of California, Davis School of Veterinary Medicine
Joseph A. Zoller: Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles
Ken Raj: Radiation Effects Department, Centre for Radiation, Chemical and Environmental Hazards, Public Health England
Brenda Larison: Department of Ecology and Evolutionary Biology, University of California
Todd R. Robeck: Zoological Operations, SeaWorld Parks and Entertainment
Jessica L. Petersen: Department of Animal Science, University of Nebraska
Rebecca R. Bellone: Department of Population Health and Reproduction, University of California, Davis School of Veterinary Medicine
Carrie J. Finno: Department of Population Health and Reproduction, University of California, Davis School of Veterinary Medicine

DOI: https://doi.org/10.1038/s41467-021-27754-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

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Methylation levels of specific sites in the genome is correlated with aging. Here the authors develop a human-horse clock which could assist in translating anti-aging interventions from humans to horses and vice versa.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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