Nature Communications (Apr 2023)
Nasopharyngeal carcinoma cells promote regulatory T cell development and suppressive activity via CD70-CD27 interaction
- Lanqi Gong,
- Jie Luo,
- Yu Zhang,
- Yuma Yang,
- Shanshan Li,
- Xiaona Fang,
- Baifeng Zhang,
- Jiao Huang,
- Larry Ka-Yue Chow,
- Dittman Chung,
- Jinlin Huang,
- Cuicui Huang,
- Qin Liu,
- Lu Bai,
- Yuen Chak Tiu,
- Pingan Wu,
- Yan Wang,
- George Sai-Wah Tsao,
- Dora Lai-wan Kwong,
- Anne Wing-Mui Lee,
- Wei Dai,
- Xin-Yuan Guan
Affiliations
- Lanqi Gong
- Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Jie Luo
- Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Yu Zhang
- Department of Pediatric Oncology, Sun Yat-sen University Cancer Center
- Yuma Yang
- Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Shanshan Li
- Department of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital
- Xiaona Fang
- Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Baifeng Zhang
- Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Jiao Huang
- Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Larry Ka-Yue Chow
- Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Dittman Chung
- Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Jinlin Huang
- Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Cuicui Huang
- Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Qin Liu
- Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Lu Bai
- Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Yuen Chak Tiu
- Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Pingan Wu
- Department of Surgery, The University of Hong Kong-Shenzhen Hospital
- Yan Wang
- Department of Pathology, The University of Hong Kong-Shenzhen Hospital
- George Sai-Wah Tsao
- School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Dora Lai-wan Kwong
- Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Anne Wing-Mui Lee
- Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Wei Dai
- Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Xin-Yuan Guan
- Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- DOI
- https://doi.org/10.1038/s41467-023-37614-6
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 24
Abstract
Response rates to immunotherapies in patients with nasopharyngeal carcinoma (NPC) are still limited. Here the authors show that tumor-restricted CD70 correlates with regulatory T cell abundance and suppressive activity in NPC and that CD70 blockade improves response to anti-PD1 in preclinical models.
