SYNTHESIS, CHARACTERIZATION AND BACTERIAL ACTIVITY OF SOME METAL COMPLEXES OF N-PHENYL- Ń-(3-CARBOXYPHENOL) THIOUREA

Abstract

A thiourea ligand; N-phenyl- Ń-(3carboxyphenol) thiourea (PCTH) is synthesized from the reaction of phenyl isothiocyanate with 3-aminobenzoic acid. Treatment of the ligand (PCTH) with metal salts MCl2, where M = Cu(II), Zn(II), Pb(II) and Co(II) gave metallic complexes of the types: 1- [M(PCTH)2Cl2] where M=Cu(II) and Co(II) and 2- [M(PCT)2] where M=Zn(II) and Pb(II). The ligand (PCTH) behaves as a bidentate and coordinated to the metal ion centers either through sulfur atom of its thioamide group and through nitrogen atom of the amine group or through oxygen atom of the carboxylic group. All the synthesized ligand metal complexes are characterized by micro-elemental analysis, IR spectroscopy and UV-Vis. spectroscopy, 1H.NMR, 13C.NMR, conductivity and magnetic susceptibility measurements. Finally, bacterial activity of the ligand (PTCH) and its metal complexes are tested against Klebsiella pneumonia and Escherichia coli and gram-positive bacteria Staphylococcus aurous. Using well-diffusion method and the results are discussed.

Keywords

• thiourea derivative
• transition metal complexes
• bacterial activity