Nature Communications (Apr 2019)
MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression
- Yao Jiang,
- Yanqiong Zhang,
- Janet Y. Leung,
- Cheng Fan,
- Konstantin I. Popov,
- Siyuan Su,
- Jiayi Qian,
- Xiaodong Wang,
- Alisha Holtzhausen,
- Eric Ubil,
- Yang Xiang,
- Ian Davis,
- Nikolay V. Dokholyan,
- Gang Wu,
- Charles M. Perou,
- William Y. Kim,
- H. Shelton Earp,
- Pengda Liu
Affiliations
- Yao Jiang
- Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Yanqiong Zhang
- Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill
- Janet Y. Leung
- Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill
- Cheng Fan
- Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill
- Konstantin I. Popov
- Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill
- Siyuan Su
- Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill
- Jiayi Qian
- Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill
- Xiaodong Wang
- Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill
- Alisha Holtzhausen
- Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill
- Eric Ubil
- Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill
- Yang Xiang
- Abclonal Technology
- Ian Davis
- Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill
- Nikolay V. Dokholyan
- Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill
- Gang Wu
- Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Charles M. Perou
- Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill
- William Y. Kim
- Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill
- H. Shelton Earp
- Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill
- Pengda Liu
- Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill
- DOI
- https://doi.org/10.1038/s41467-019-09233-7
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
Hyperactivation of Akt promotes tumorigenesis. Here, the authors show that SAV1, a member of Hippo signalling, interacts with Akt to suppress Akt activity and MERTK-mediated Akt phosphorylation relieves this suppression to facilitate Akt oncogenic activity in clear cell renal carcinomas.
