Nature Communications (Sep 2016)

Structural basis of synaptic vesicle assembly promoted by α-synuclein

  • Giuliana Fusco,
  • Tillmann Pape,
  • Amberley D. Stephens,
  • Pierre Mahou,
  • Ana Rita Costa,
  • Clemens F. Kaminski,
  • Gabriele S. Kaminski Schierle,
  • Michele Vendruscolo,
  • Gianluigi Veglia,
  • Christopher M. Dobson,
  • Alfonso De Simone

DOI
https://doi.org/10.1038/ncomms12563
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 12

Abstract

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α-synuclein, a protein associated to Parkinson's disease, is involved in synaptic vesicle interaction and assembly. Here, the authors use NMR spectroscopy and super-resolution microscopy to unveil the nature and molecular mechanism of α-synuclein-mediated synaptic vesicle clustering.