Российский офтальмологический журнал (Oct 2018)

Results of Laboratory Diagnostics of the Human herpes virus Type 6 in Various Forms of Eye Diseases

  • E. V. Svetlova,
  • O. S. Slepova,
  • E. V. Denisova,
  • L. A. Kovaleva,
  • E. A. Eremeeva,
  • P. V. Makarov,
  • A. E. Kugusheva,
  • E. S. Vakhova,
  • A. E. Andryushin,
  • V. V. Demkin

DOI
https://doi.org/10.21516/2072-0076-2016-9-1-73-77
Journal volume & issue
Vol. 9, no. 1
pp. 73 – 77

Abstract

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To study the role of HHV-6 in the development of eye diseases, 193 patients with various eye diseases were examined. Using polymerase chain reaction (PCR) tests DNA of HHV-6 (n = 146) in peripheral blood was detected, using immunoferment analysis markers of chronic (IgG antibodies, n = 142) and active (IgM antibodies, n = 74) HHV-6 infection were detected in blood serum. HHV-6 could be detected in patients with different ophthalmic pathology forms both in the chronic (66.9 %) and the active (43.2 %) form, and DNA of the virus could be found in the blood (20.5 %). A parallel simultaneous study of the blood (n = 40) revealed markers of chronic and/or active infection and DNA of the virus in patients of all nosological groups surveyed (uveitis, corneal ulcers of various etiologies, post-inflammatory cataracts, corneoscleral eye injuries and corneal graft disease). For the first time serological tests (IgG and IgM antibodies) were performed on patients with age-related macular degeneration, where 82.4 % of the patients turned out to be seropositive. The obtained data suggest that HHV-6, along with other viruses generally known to be ophthalmic, may be an etiologic or pathogenetic factor of eye diseases. In this regard, a comprehensive laboratory testing (serological diagnostics and PCR) for HHV-6 should become the object of further targeted study // Russian Ophthalmological Journal, 2016; 1: 73-77.

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