Nature Communications (Apr 2016)

Iterative protecting group-free cross-coupling leading to chiral multiply arylated structures

  • Cathleen M. Crudden,
  • Christopher Ziebenhaus,
  • Jason P. G. Rygus,
  • Kazem Ghozati,
  • Phillip J. Unsworth,
  • Masakazu Nambo,
  • Samantha Voth,
  • Marieke Hutchinson,
  • Veronique S. Laberge,
  • Yuuki Maekawa,
  • Daisuke Imao

DOI
https://doi.org/10.1038/ncomms11065
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 7

Abstract

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The Suzuki-Miyaura cross coupling is widely used in industrial and academic settings for the formation of carbon-carbon bonds. Here, the authors report a procedure whereby a molecule with multiple reactive carbon-boron bonds can undergo sequential, selective Suzuki-Miyaura reactions without the need for protecting groups.