Novel insights into D-Pinitol based therapies: a link between tau hyperphosphorylation and insulin resistance

Abstract

Alzheimer’s disease is a neurodegenerative disorder characterized by the amyloid accumulation in the brains of patients with Alzheimer’s disease. The pathogenesis of Alzheimer’s disease is mainly mediated by the phosphorylation and aggregation of tau protein. Among the multiple causes of tau hyperphosphorylation, brain insulin resistance has generated much attention, and inositols as insulin sensitizers, are currently considered candidates for drug development. The present narrative review revises the interactions between these three elements: Alzheimer’s disease-tau-inositols, which can eventually identify targets for new disease modifiers capable of bringing hope to the millions of people affected by this devastating disease.

Keywords

• alzheimer’s disease; cyclin-dependent kinase 5; diabetes; d-pinitol; inositols; insulin resistance; kinases; phosphorylation; pi3k/akt; tau