Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul (Apr 2003)
Induction ovulation with use of low dose HMG in patients with Clomiphene Citrate resistant polycystic ovary syndrome (PCOs)
Abstract
Background and Objective: The aim of this study was to assess the follicular response in induction of ovulation with the of low dose human menopausal gonadotropin (HMG) in patients with clomiphene citrate resistant PCOs. Methods: This semi-experimental study was performed on 12 patients with clomiphene citrate resistant PCOs in Fatemeh Zahra infertility center. Induction ovulation was started with 37.5 (IU) of HMG daily and then was increased by 75IU according to follicular response. Patients were exactly monitored by vaginal sonography. Findings: Eight patients showed suitable follicular response to induction, of whom 2 conceived. In 4 patients, their cycles had cancelled because no follicular response was observed in spite of increasing dose to 75IU until midcycle. Ovarian hyperstimulation syndrome (OHSS) was not observed in any of them. Conclusion: Administration of low dose HMG can be used successfully to stimulate follicular growth in patients with clomiphene citrate resistant PCOs.
