Frontiers in Neurology (Nov 2019)

Spontaneous Intracerebral Hemorrhage Due to Delta Storage Pool Disease in a Patient on a Serotonin-Norepinephrine Reuptake Inhibitor

  • Annette Leibetseder,
  • Judith Wagner,
  • Josef Tomasits,
  • Hans-Peter Haring,
  • Markus Hutterer,
  • Johannes Trenkler,
  • Tim J. von Oertzen

DOI
https://doi.org/10.3389/fneur.2019.01257
Journal volume & issue
Vol. 10

Abstract

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We report a case of spontaneous intracerebral hemorrhage (sICH) due to delta storage pool disease in a 60-year-old female on a serotonin-norepinephrine reuptake inhibitor (SNRI). Increased susceptibility to SNRI-effects on hemostasis was due to a genetic disposition mediated by a polymorphism of the SLC6A4 gene coding for the human serotonin transporter (SERT). Pathophysiological and clinical implications of these findings are discussed.

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