Evaluation of toxic effects of chemotherapy in lung malignancies on cerebral white matter using diffusion tensor imaging

Abstract

Non-small cell lung cancer (NSCLC) is a leading cause of morbidity and mortality. Carboplatin and cisplatin based regimens are used in the treatment of NSCLC. The aim of the study was to find out whether there is a difference in white matter (WM) changes between two platinum-based chemotherapy agents using diffusion tensor imaging (DTI).

Keywords

• diffusion tensor imaging
• chemotherapy
• carboplatin
• cisplatin
• carcinoma
• non-small-cell lung cancer