Serum neurofilament light levels in normal aging and their association with morphologic brain changes

Michael Khalil; Lukas Pirpamer; Edith Hofer; Margarete M. Voortman; Christian Barro; David Leppert; Pascal Benkert; Stefan Ropele; Christian Enzinger; Franz Fazekas; Reinhold Schmidt; Jens Kuhle

doi:10.1038/s41467-020-14612-6

Nature Communications (Feb 2020)

Serum neurofilament light levels in normal aging and their association with morphologic brain changes

Michael Khalil,
Lukas Pirpamer,
Edith Hofer,
Margarete M. Voortman,
Christian Barro,
David Leppert,
Pascal Benkert,
Stefan Ropele,
Christian Enzinger,
Franz Fazekas,
Reinhold Schmidt,
Jens Kuhle

Affiliations

Michael Khalil: Department of Neurology, Medical University of Graz
Lukas Pirpamer: Department of Neurology, Medical University of Graz
Edith Hofer: Department of Neurology, Medical University of Graz
Margarete M. Voortman: Department of Neurology, Medical University of Graz
Christian Barro: Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel
David Leppert: Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel
Pascal Benkert: Clinical Trial Unit, Department of Clinical Research, University Hospital Basel, University of Basel
Stefan Ropele: Department of Neurology, Medical University of Graz
Christian Enzinger: Department of Neurology, Medical University of Graz
Franz Fazekas: Department of Neurology, Medical University of Graz
Reinhold Schmidt: Department of Neurology, Medical University of Graz
Jens Kuhle: Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel

DOI: https://doi.org/10.1038/s41467-020-14612-6
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 9

Abstract

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Neurofilament (NfL) levels in CSF and blood have been established as a biomarker of neuronal damage in neurodegenerative diseases, and there is an age-dependent increase in NfL levels in CSF. Here the authors demonstrate that serum NfL levels increase in healthy aging people and predict and correlate with brain volume loss.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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