CA125-Associated Activated Partial Thromboplastin Time and Thrombin Time Decrease in Patients with Adenomyosis

Abstract

Fanchun Yang, Qingying Wang, Rui Ma, Fangzhen Deng, Jie Liu Department of Obstetrics and Gynecology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of ChinaCorrespondence: Jie Liu, Department of Obstetrics and Gynecology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, No. 301, Yanchang Zhong Road, Shanghai, People’s Republic of China, Email [email protected]: Adenomyosis patients are in a hypercoagulable state, and studies have shown that carbohydrate antigen125 (CA125) may relate to the hypercoagulability and thrombosis of patients with adenomyosis, but there is still a lack of clarity regarding the changes in CA125-related coagulation indicators. This study was to explore the changes and influencing factors of CA125-related coagulation parameters in patients with adenomyosis.Methods: Retrospective observational study conducted on 200 patients with adenomyosis (AM group), 240 patients with uterine leiomyoma (LM group) and 81 patients with cervical intraepithelial neoplasia (CIN)-III (control group), of which the coagulation parameters were detected by clinical blood sample collection and statistical method analysis and informed consent was obtained.Results: The level of CA125 in the AM group was significantly higher than that in the LM group and control group. However, thrombin time (TT) shortened in the AM group when compared with the LM and control group. Activated partial thromboplastin time (APTT) in the AM group was shorter than in the control group. Multivariate logistic regression analysis found that adenomyosis was associated with CA125 level (OR=323.860, 95% CI 90.424– 1159.924, P< 0.001), APTT (OR=1.295, 95% CI 1.050– 1.598, P=0.016), TT (OR=0.642, 95% CI 0.439– 0.938, P=0.022), menorrhagia (OR=7.363, 95% CI 2.544– 21.315, P< 0.001), dysmenorrhea (OR=22.590, 95% CI 8.185– 62.347, P< 0.001). Correlation analysis revealed that APTT (r= − 0.207) and TT (r = − 0.174) were negatively correlated with the level of CA125.Conclusion: The shortening of CA125-related APTT and TT indicates that it is meaningful to detect coagulation parameters of patients with elevated CA125 levels early, dysmenorrhea and menorrhagia, and maybe further discover the hypercoagulability and prevent the occurrence of thrombus in adenomyosis.Keywords: adenomyosis, coagulation parameters, hypercoagulability, CA125, APTT, TT

Keywords

• adenomyosis
• coagulation parameters
• hypercoagulability
• ca125
• aptt
• tt.