Nature Communications (May 2022)

Origins of glycan selectivity in streptococcal Siglec-like adhesins suggest mechanisms of receptor adaptation

  • Barbara A. Bensing,
  • Haley E. Stubbs,
  • Rupesh Agarwal,
  • Izumi Yamakawa,
  • Kelvin Luong,
  • Kemal Solakyildirim,
  • Hai Yu,
  • Azadeh Hadadianpour,
  • Manuel A. Castro,
  • Kevin P. Fialkowski,
  • KeAndreya M. Morrison,
  • Zdzislaw Wawrzak,
  • Xi Chen,
  • Carlito B. Lebrilla,
  • Jerome Baudry,
  • Jeremy C. Smith,
  • Paul M. Sullam,
  • T. M. Iverson

DOI
https://doi.org/10.1038/s41467-022-30509-y
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 14

Abstract

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Streptococcal siglec-like binding regions (SLBRs) selectively bind cell surface glycans, but the basis for this selectivity is not understood. Here, the authors identify selectivity-modulating SLBR regions and study how changes in SLBR glycan selectivity affect interactions with human glycoprotein receptors.