Nature Communications (May 2022)
Origins of glycan selectivity in streptococcal Siglec-like adhesins suggest mechanisms of receptor adaptation
- Barbara A. Bensing,
- Haley E. Stubbs,
- Rupesh Agarwal,
- Izumi Yamakawa,
- Kelvin Luong,
- Kemal Solakyildirim,
- Hai Yu,
- Azadeh Hadadianpour,
- Manuel A. Castro,
- Kevin P. Fialkowski,
- KeAndreya M. Morrison,
- Zdzislaw Wawrzak,
- Xi Chen,
- Carlito B. Lebrilla,
- Jerome Baudry,
- Jeremy C. Smith,
- Paul M. Sullam,
- T. M. Iverson
Affiliations
- Barbara A. Bensing
- Division of Infectious Diseases, Veterans Affairs Medical Center, Department of Medicine, University of California
- Haley E. Stubbs
- Graduate Program in Chemical and Physical Biology, Vanderbilt University
- Rupesh Agarwal
- University of Tennessee/Oak Ridge National Laboratory, Center for Molecular Biophysics, Biosciences Division, Oak Ridge National Laboratory
- Izumi Yamakawa
- Department of Pharmacology, Vanderbilt University
- Kelvin Luong
- Department of Pharmacology, Vanderbilt University
- Kemal Solakyildirim
- Department of Chemistry, Erzincan Binali Yildirim University
- Hai Yu
- Department of Chemistry, University of California
- Azadeh Hadadianpour
- Department of Microbiology, Pathology, and Immunology, Vanderbilt University
- Manuel A. Castro
- Department of Biochemistry, Vanderbilt University
- Kevin P. Fialkowski
- Department of Pharmacology, Vanderbilt University
- KeAndreya M. Morrison
- Department of Pharmacology, School of Graduate Studies and Research, Meharry Medical College
- Zdzislaw Wawrzak
- LS-CAT Synchrotron Research Center, Northwestern University
- Xi Chen
- Department of Chemistry, University of California
- Carlito B. Lebrilla
- Department of Chemistry, University of California
- Jerome Baudry
- Department of Biological Sciences, The University of Alabama in Huntsville
- Jeremy C. Smith
- University of Tennessee/Oak Ridge National Laboratory, Center for Molecular Biophysics, Biosciences Division, Oak Ridge National Laboratory
- Paul M. Sullam
- Division of Infectious Diseases, Veterans Affairs Medical Center, Department of Medicine, University of California
- T. M. Iverson
- Department of Pharmacology, Vanderbilt University
- DOI
- https://doi.org/10.1038/s41467-022-30509-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Streptococcal siglec-like binding regions (SLBRs) selectively bind cell surface glycans, but the basis for this selectivity is not understood. Here, the authors identify selectivity-modulating SLBR regions and study how changes in SLBR glycan selectivity affect interactions with human glycoprotein receptors.
