Mechanism and structural diversity of exoribonuclease-resistant RNA structures in flaviviral RNAs

Andrea MacFadden; Zoe O’Donoghue; Patricia A. G. C. Silva; Erich G. Chapman; René C. Olsthoorn; Mark G. Sterken; Gorben P. Pijlman; Peter J. Bredenbeek; Jeffrey S. Kieft

doi:10.1038/s41467-017-02604-y

Nature Communications (Jan 2018)

Mechanism and structural diversity of exoribonuclease-resistant RNA structures in flaviviral RNAs

Andrea MacFadden,
Zoe O’Donoghue,
Patricia A. G. C. Silva,
Erich G. Chapman,
René C. Olsthoorn,
Mark G. Sterken,
Gorben P. Pijlman,
Peter J. Bredenbeek,
Jeffrey S. Kieft

Affiliations

Andrea MacFadden: Department of Biochemistry and Molecular Genetics, University of Colorado Denver School of Medicine
Zoe O’Donoghue: Department of Biochemistry and Molecular Genetics, University of Colorado Denver School of Medicine
Patricia A. G. C. Silva: Department of Medical Microbiology, Leiden University Medical Center
Erich G. Chapman: Department of Biochemistry and Molecular Genetics, University of Colorado Denver School of Medicine
René C. Olsthoorn: Leiden Institute of Chemistry, Leiden University
Mark G. Sterken: Laboratory of Virology, Wageningen University
Gorben P. Pijlman: Laboratory of Virology, Wageningen University
Peter J. Bredenbeek: Department of Medical Microbiology, Leiden University Medical Center
Jeffrey S. Kieft: Department of Biochemistry and Molecular Genetics, University of Colorado Denver School of Medicine

DOI: https://doi.org/10.1038/s41467-017-02604-y
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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Subgenomic flavivirus RNAs are generated by a host exoribonuclease and play an important role in virus replication and pathogenesis. Here, the authors show the mechanism by which subgenomic flavivirus RNAs are generated and identify two structurally distinct sfRNA classes in flaviviruses.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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