Sonogenetics: Recent advances and future directions

Tianyi Liu; Mi Hyun Choi; Jiejun Zhu; Tingting Zhu; Jin Yang; Na Li; Zihao Chen; Quanxiang Xian; Xuandi Hou; Dongmin He; Jinghui Guo; Chunlong Fei; Lei Sun; Zhihai Qiu

Brain Stimulation (Sep 2022)

Sonogenetics: Recent advances and future directions

Tianyi Liu,
Mi Hyun Choi,
Jiejun Zhu,
Tingting Zhu,
Jin Yang,
Na Li,
Zihao Chen,
Quanxiang Xian,
Xuandi Hou,
Dongmin He,
Jinghui Guo,
Chunlong Fei,
Lei Sun,
Zhihai Qiu

Affiliations

Tianyi Liu: Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong, 519031, China
Mi Hyun Choi: Department of Bioengineering, Stanford University, CA, USA
Jiejun Zhu: Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong, 519031, China
Tingting Zhu: Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong, 519031, China
Jin Yang: Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong, 519031, China
Na Li: Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong, 519031, China; School of Microelectronics, Xidian University, Xi'an, China
Zihao Chen: Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong, 519031, China; School of Microelectronics, Xidian University, Xi'an, China
Quanxiang Xian: Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, China
Xuandi Hou: Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, China
Dongmin He: Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong, 519031, China
Jinghui Guo: Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, China; Department of Physiology, Faculty of Medicine, Jinan University, Guangzhou, China
Chunlong Fei: School of Microelectronics, Xidian University, Xi'an, China
Lei Sun: Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, China; Corresponding author.
Zhihai Qiu: Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong, 519031, China; Corresponding author.

Journal volume & issue: Vol. 15, no. 5
pp. 1308 – 1317

Abstract

Read online

Sonogenetics refers to the use of genetically encoded, ultrasound-responsive mediators for noninvasive and selective control of neural activity. It is a promising tool for studying neural circuits. However, due to its infancy, basic studies and developments are still underway, including gauging key in vivo performance metrics such as spatiotemporal resolution, selectivity, specificity, and safety. In this paper, we summarize recent findings on sonogenetics to highlight technical hurdles that have been cleared, challenges that remain, and future directions for optimization.

Published in Brain Stimulation

ISSN: 1935-861X (Print); 1876-4754 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/brain-stimulation

About the journal