Biomedicines (Jun 2022)

CT-Detected MTA Score Related to Disability and Behavior in Older People with Cognitive Impairment

  • Michele Lauriola,
  • Grazia D’Onofrio,
  • Annamaria la Torre,
  • Filomena Ciccone,
  • Carmela Germano,
  • Leandro Cascavilla,
  • Antonio Greco

DOI
https://doi.org/10.3390/biomedicines10061381
Journal volume & issue
Vol. 10, no. 6
p. 1381

Abstract

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Our study aims to investigate the relationship between medial temporal lobe atrophy (MTA) score, assessed by computed tomography (CT) scans, and functional impairment, cognitive deficit, and psycho-behavioral disorder severity. Overall, 239 (M = 92, F = 147; mean age of 79.3 ± 6.8 years) patients were evaluated with cognitive, neuropsychiatric, affective, and functional assessment scales. MTA was evaluated from 0 (no atrophy) to 4 (severe atrophy). The homocysteine serum was set to two levels: between 0 and 10 µmol/L, and >10 µmol/L. The cholesterol and glycemia blood concentrations were measured. Hypertension and atrial fibrillation presence/absence were collected. A total of 14 patients were MTA 0, 44 patients were MTA 1, 63 patients were MTA 2, 79 patients were MTA 3, and 39 patients were MTA 4. Cognitive (p p p p p p = 0.001) increased according to MTA severity. This study encourages and supports the potential role of MTA score and CT scan in the field of neurodegenerative disorder research and diagnosis.

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