Influence of bacteriophages on sensitivity of conditionally pathogenic bacteria to antibacterial prepar ations

Abstract

Aim. Study of the influence of bacteriophages on the formation of resistance of opportunistic bacteria to antibacterial drugs. Materials and methods. The sensitivity of 108 strains of Staphylococcus aureus to the staphylococcus bacteriophage, 97 strains of bacteria of the genus Klebsiella to the bacteriophage Klebsiella polyvalent, and also to antibacterial preparations before and after interaction with a specific bacteriophage has been studied. Results. The sensitivity of S. aureus bacteria to the staphylococcus bacteriophage was 66.7%, the lytic activity of the Klebsiella bacteriophage was polyvalent for strains of the Klebsiella genus, 83.5%. A decrease in the number of sensitive and moderately resistant strains of S. aureus to antibacterial drugs after interaction with a specific bacteriophage has been reported. The number of bacteria sensitive to antibiotics of the genus Klebsiella increased under the influence of the Klebsiella bacteriophage. Conclusion. The results of the study testify to the multidirectional influence of bacteriophages on the antibiotic susceptibility of opportunistic cultures and the need for additional study of this issue with the help of modern molecular genetic methods of research.

Keywords

• conditionally pathogenic microflora
• bacteriophages
• antibiotic resistance