Intensive Combination LDL-Lowering Therapy in a Patient With Homozygous Familial Hypercholesterolemia

Hayato Tada, MD; Hirofumi Okada, MD; Masa-aki Kawashiri, MD; Masayuki Takamura, MD

JACC: Case Reports (Jun 2024)

Intensive Combination LDL-Lowering Therapy in a Patient With Homozygous Familial Hypercholesterolemia

Hayato Tada, MD,
Hirofumi Okada, MD,
Masa-aki Kawashiri, MD,
Masayuki Takamura, MD

Affiliations

Hayato Tada, MD: Address for correspondence: Dr Hayato Tada, Department of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa 920-8641, Japan.; Department of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan
Hirofumi Okada, MD: Department of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan
Masa-aki Kawashiri, MD: Department of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan
Masayuki Takamura, MD: Department of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan

Journal volume & issue: Vol. 29, no. 12
p. 102367

Abstract

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We present a young boy with a diagnosis of homozygous familial hypercholesterolemia who presented with statin and ezetimibe resistance. The patient received lipoprotein apheresis at 6 years of age. His low-density lipoprotein cholesterol levels significantly were reduced by adding lomitapide and evinacumab, and his carotid plaque started to regress.

Published in JACC: Case Reports

ISSN: 2666-0849 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/jacc-case-reports

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Abstract

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