Brazilian Journal of Pharmaceutical Sciences (Nov 2023)

Association of serum lipoproteins and inflammatory parameters derived from the blood test with renal function in COVID-19 outpatients

  • Glautemberg de Almeida Viana,
  • Mac Dionys Rodrigues da Costa,
  • Mateus Edson da Silva,
  • Victória da Costa Silva,
  • Arif Ali,
  • Erlânia Alves de Siqueira,
  • Renata de Sousa Alves,
  • Alice Maria Costa Martins,
  • Ramon Róseo Paula Pessoa Bezerra de Menezes,
  • Maria Goretti Rodrigues de Queiroz,
  • Tiago Lima Sampaio

DOI
https://doi.org/10.1590/s2175-97902023e23293
Journal volume & issue
Vol. 59

Abstract

Read online

Abstract Changes in lipoprotein metabolism are among the main causes of hemodynamic impairment in renal function. COVID-19 is an multisystemic inflammatory disease, aggravating this situation. This cross-sectional study investigated the relationship of serum lipoprotein profile with inflammatory parameters and renal function in 95 COVID-19 outpatients in comparison with 173 with flu-like symptoms. Serum samples were collected for the determination of total cholesterol and fractions, apolipoproteins (Apo A-I and Apo B), urea (sUr) and creatinine (sCr). The glomerular filtration rate (eGFR) was calculated. Neutrophil/lymphocyte (NLR) and platelet/lymphocyte (PLR) ratios were calculated as inflammatory parameters derived from the blood tests. COVID-19 patients presented lower high-density lipoprotein cholesterol (HDL-c) (47.90 ± 1.543 vs. 51.40 ± 0.992) and higher PLR (190.9 ± 9.410 vs. 137.6 ± 5.534) and NLR (3.40 ± 0.22 vs. 2.80 ± 0.15). Both NLR and PLR correlated with each other (r = 0.639). Furthermore, the Apo B/Apo A-I ratio was correlated with PLR (r = 0.5818) and eGFR (r = -0.2630). COVID-19 patients classified as at high risk of developing acute myocardial infarction based on the Apo B/ Apo A-I ratio had higher values for sUr/sCr. Thus, serum apolipoproteins, PLR, and NLR could be related to renal dysfunction in COVID-19.

Keywords