Noninvasive diagnostics for colorectal cancer: molecular genetic fecal DNA analysis

Abstract

Colorectal cancer (CRC) is still one of the leading causes of cancer-related death all over the world. An early diagnosis is fundamental thing for reducing the CRC-related morbidity and mortality. Nowadays researchers are studying more reliable and effective non-invasive screening tests, using easily available biological samples, such as feces. Such methods have high potential to collect and deliver samples. The comparison of some new variants genomic fecal DNA analysis and traditional fecal occult blood tests are discussed in this review. Sensitivity, specificity of the methods, processability, efficacy and ability of early CRC screening are the criteria for the preference of the using of one of these methods. These factors give the opportunity to carry out the large-scale CRC screening. This technological advance promises to increase the efficiency of the fecal DNA analysis and put the using of new clinical applications.

Keywords

• ранняя диагностика колоректального рака
• молекулярно-генетические методы
• анализ фекальной днк
• тест на скрытую кровь
• early diagnostics of colorectal cancer
• molecular genetic methods
• fecal dna analysis
• fecal occult blood testing