Cancer Management and Research (Apr 2021)

The Prognosis Value of PSPC1 Expression in Nasopharyngeal Cancer

  • He H,
  • Zhang L,
  • Lin K,
  • Huang Z,
  • Zhou Y,
  • Lin S,
  • Su Y,
  • Pan J

Journal volume & issue
Vol. Volume 13
pp. 3281 – 3291

Abstract

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Huocong He,1,*,* Lurong Zhang,1,* Keyu Lin,1,* Zhengrong Huang,2 Yan Zhou,3 Shaojun Lin,4 Ying Su,1 Jianru Pan5 1Laboratory of Radiation Biology, Fujian Cancer Hospital & Fujian Medical University Cancer Hospital, Fuzhou, Fujian, 350014, People’s Republic of China; 2Department of Integrative Medicine, Fujian Cancer Hospital & Fujian Medical University Cancer Hospital, Fuzhou, Fujian, 350014, People’s Republic of China; 3Department of Epidemiology, Fujian Cancer Hospital & Fujian Medical University Cancer Hospital, Fuzhou, Fujian, 350014, People’s Republic of China; 4Department of Radiation Oncology, Fujian Cancer Hospital & Fujian Medical University, Fuzhou, Fujian, 350014, People’s Republic of China; 5College of Biological Science and Engineering, Fuzhou University, Fuzhou, Fujian, 350002, People’s Republic of China*These authors contributed equally to this workCorrespondence: Huocong HeLaboratory of Radiation Biology, Fujian Cancer Hospital & Fujian Medical University Cancer Hospital, Fuzhou, Fujian, 350014, People’s Republic of ChinaEmail [email protected] PanCollege of Biological Science and Engineering, Fuzhou University, Fuzhou, Fujian, 350002, People’s Republic of ChinaEmail [email protected]: Paraspeckle component 1 (PSPC1) is overexpressed in various cancer and correlated with poor survival in the patients. However, little is known about its expression and role in the progression of nasopharyngeal carcinomas (NPC). The purpose of this study is to examine PSPC1 expression in NPC and explore its role in clinical prognosis of radiation therapy.Methods: The association of PSPC1 expression with clinicopathological features of 109 NPC patients was examined using partial correlation analysis. Cancer tissues were obtained prior to clinical treatment. All cases were diagnosed and pathologically confirmed to be poorly differentiated or undifferentiated NPC without distant metastasis. The patients were then treated with radiation and followed-up. Survival analysis was performed.Results: Partial correlation analysis revealed that the PSPC1 expression in NPC was correlated with N classification, recurrence, prognosis and radiosensitivity in NPC patients, but not with the gender, age, pathohistological pattern, clinical stage, and T classification. The overexpression of PSPC1 was detected in 64 samples (58.72%). Kaplan–Meier survival analysis revealed that the overall survival (OS) was longer in NPC patients with PSPC1 low expression than that in those with PSPC1 high expression. Moreover, patients with the overexpression of PSPC1 had a low progression-free survival and distant metastasis-free survival rate, compared to those who had a low expression of PSPC1. Although not statistically significant, patients with high expression of PSPC1 had a lower locoregional recurrence-free survival rate than those with low expression, and the curves between the two groups was well separated.Conclusion: PSPC1 overexpression was associated with poor prognosis for NPC, which might be a novel useful biomarker to predict the response of NPC to radiation therapy and its clinical outcome.Keywords: nasopharyngeal carcinoma, paraspeckle component 1, PSPC1, clinical prognosis, radiation, overexpression

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