Journal of Isotopes (Aug 2016)
The Acute Toxicity and Pharmacokinetics of the BSH
Abstract
In this study, the acute toxicity of BSH was studied at doses of 210, 300, 430, 614 mg/kg, and the LD50 was calculated at 381.94 mg/kg. A three-compartment model system was used to evaluate the pharmacokinetics of the BSH, and the pharmacokinetic parameters, such as t1/2,Vd, AUC, CL of BSH were calculated: t1/2α=3.6 min, t1/2β=55.8 min, t1/2γ=6.26 h, Vd=3 523.58 mL/kg, AUC= 247.55 hr*μg/mL, CL=3572.45 mL/hr/kg. The biodistribution of the BSH was studied in normal mice, from which the characteristics of biodistribution of BSH was analyzed.
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