Iranian South Medical Journal (Dec 2010)

A case of Mantle Cell Lymphoma with Multiple Lymphomatous Polyposis

  • Seyed Masoud Tabib,
  • Mohammadreza Ravanbod,
  • Seyed Mohammad Valizadeh,
  • Mohammadreza Farzaneh

Journal volume & issue
Vol. 13, no. 4
pp. 293 – 298

Abstract

Read online

Multiple Lymphomatous Polyposis (MLP) is characterized by multiple polyps involving long segments of the GI tract. More than 75% of the cases are derived from pregerminal center B cells (mantle zone B cells) & less than 25% from germinal center B cells. Thus MLP is a heterogenous group that includes Mantle Cell Lymphoma (MCL) & Follicular Lymphoma (FL). Here we present a 75-year-old sailor who referred to us with abdominal pain, bloody diarrhea, iron deficiency anemia & lymphadenopathy in inguinal & femoral regions. The presence of intestinal polyposis in colonoscopic & endoscopic evaluations & the pathologic & immunohistochemical findings on tissue specimens that showed B cell lymphoma with moderate proliferative activity (50%) & nodular proliferation of small lymphocytes accompanied with positivity for CD5, CD20, CD43 & negativity for CD3, CD10, CD23 revealed that these findings are consequent to MCL with accompanied MLP.

Keywords