Frontiers in Pharmacology (Aug 2022)
Progress on structural modification of Tetrandrine with wide range of pharmacological activities
- Liuying Mo,
- Liuying Mo,
- Liuying Mo,
- Fan Zhang,
- Fan Zhang,
- Fan Zhang,
- Fan Zhang,
- Feng Chen,
- Feng Chen,
- Feng Chen,
- Lei Xia,
- Lei Xia,
- Lei Xia,
- Yi Huang,
- Yuemi Mo,
- Yuemi Mo,
- Yuemi Mo,
- Lingqiu Zhang,
- Lingqiu Zhang,
- Lingqiu Zhang,
- Daquan Huang,
- Shunli He,
- Jiagang Deng,
- Jiagang Deng,
- Jiagang Deng,
- Erwei Hao,
- Erwei Hao,
- Erwei Hao,
- Zhengcai Du,
- Zhengcai Du,
- Zhengcai Du
Affiliations
- Liuying Mo
- Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, China
- Liuying Mo
- Guangxi Collaborative Innovation Center of Study on Functional Ingredients of Agricultural Residues, Nanning, China
- Liuying Mo
- Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Nanning, China
- Fan Zhang
- Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, China
- Fan Zhang
- Guangxi Collaborative Innovation Center of Study on Functional Ingredients of Agricultural Residues, Nanning, China
- Fan Zhang
- Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Nanning, China
- Fan Zhang
- Guangxi International Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, China
- Feng Chen
- Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, China
- Feng Chen
- Guangxi Collaborative Innovation Center of Study on Functional Ingredients of Agricultural Residues, Nanning, China
- Feng Chen
- Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Nanning, China
- Lei Xia
- Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, China
- Lei Xia
- Guangxi Collaborative Innovation Center of Study on Functional Ingredients of Agricultural Residues, Nanning, China
- Lei Xia
- Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Nanning, China
- Yi Huang
- Office of the President, Guangxi University of Chinese Medicine, Nanning, China
- Yuemi Mo
- Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, China
- Yuemi Mo
- Guangxi Collaborative Innovation Center of Study on Functional Ingredients of Agricultural Residues, Nanning, China
- Yuemi Mo
- Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Nanning, China
- Lingqiu Zhang
- Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, China
- Lingqiu Zhang
- Guangxi Collaborative Innovation Center of Study on Functional Ingredients of Agricultural Residues, Nanning, China
- Lingqiu Zhang
- Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Nanning, China
- Daquan Huang
- Guangxi Dahai Sunshine Pharmaceutical, Nanning, China
- Shunli He
- Guangxi Heli Pharmaceutical, Nanning, China
- Jiagang Deng
- Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, China
- Jiagang Deng
- Guangxi Collaborative Innovation Center of Study on Functional Ingredients of Agricultural Residues, Nanning, China
- Jiagang Deng
- Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Nanning, China
- Erwei Hao
- Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, China
- Erwei Hao
- Guangxi Collaborative Innovation Center of Study on Functional Ingredients of Agricultural Residues, Nanning, China
- Erwei Hao
- Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Nanning, China
- Zhengcai Du
- Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, China
- Zhengcai Du
- Guangxi Collaborative Innovation Center of Study on Functional Ingredients of Agricultural Residues, Nanning, China
- Zhengcai Du
- Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Nanning, China
- DOI
- https://doi.org/10.3389/fphar.2022.978600
- Journal volume & issue
-
Vol. 13
Abstract
Tetrandrine (Tet), derived from the traditional Chinese herb Fangji, is a class of natural alkaloids with the structure of bisbenzylisoquinoline, which has a wide range of physiological activities and significant pharmacfological effects. However, studies and clinical applications have revealed a series of drawbacks such as its poor water solubility, low bioavailability, and the fact that it can be toxic to humans. The results of many researchers have confirmed that chemical structural modifications and nanocarrier delivery can address the limited application of Tet and improve its efficacy. In this paper, we summarize the anti-tumor efficacy and mechanism of action, anti-inflammatory efficacy and mechanism of action, and clinical applications of Tet, and describe the progress of Tet based on chemical structure modification and nanocarrier delivery, aiming to explore more diverse structures to improve the pharmacological activity of Tet and provide ideas to meet clinical needs.
Keywords
- tetrandrine (TET)
- poor water solubility
- low bioavailability
- structure modification
- nanocarrier delivery systems
