Phosphoinositide phosphatases and disease

Abstract

The field of inositol signaling has expanded greatly in recent years. Given the many reviews on phosphoinositide kinases, we have chosen to restrict our discussion to inositol lipid hydrolysis focused on the phosphatases and a brief mention of the lipase isoforms. We also discuss recent discoveries that link mutations in phosphoinositide phosphatases to disease.

Keywords

• membrane trafficking
• lipid code
• kinase
• myotubularin
• Lowe syndrome
• Charcot-Marie-Tooth disease