Revista da Sociedade Brasileira de Medicina Tropical (Oct 2022)

Endophytic fungus Phomopsis sp. as a source of 3-nitropropionic acid with larvicidal activity against Aedes aegypti (Linnaeus 1762, Diptera: Culicidae)

  • Armando da Costa Garcia,
  • Orivaldo Teixeira de Menezes Júnior,
  • Lissa Apolonia Mariano,
  • Letícia Corrêa Santiago,
  • Ângela Regina Araújo,
  • Julia Dietsche Monfardini,
  • Rejane de Castro Simões,
  • André Correa de Oliveira,
  • Rosemary Aparecida Roque,
  • Wanderli Pedro Tadei,
  • Helder Lopes Teles,
  • Camila Martins de Oliveira

DOI
https://doi.org/10.1590/0037-8682-0018-2022
Journal volume & issue
Vol. 55

Abstract

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ABSTRACT Background: Aedes aegypti is the primary vector of viruses, such as Zika, chikungunya, yellow fever, and dengue. In this context, a biomonitored chemical study was conducted to evaluate the activity of the crude extract of the endophytic fungus Phomopsis sp. against the larvae of Aedes aegypti. Methods: Crude extract, fractions, and isolated substances were evaluated in in-vitro assays against third-stage larvae of Aedes aegypti. Results: We isolated 3-nitropropionic acid with an LC50 of 15.172 ppm and LC90 of 18.178 ppm after 24 hours of larval exposure. Conclusions: The results indicated that 3-nitropropionic acid exerted larvicidal activity.

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