Non-Enzymatic Modification of Aminophospholipids by Carbonyl-Amine Reactions

Abstract

Non-enzymatic modification of aminophospholipids by lipid peroxidation-derived aldehydes and reducing sugars through carbonyl-amine reactions are thought to contribute to the age-related deterioration of cellular membranes and to the pathogenesis of diabetic complications. Much evidence demonstrates the modification of aminophospholipids by glycation, glycoxidation and lipoxidation reactions. Therefore, a number of early and advanced Maillard reaction-lipid products have been detected and quantified in different biological membranes. These modifications may be accumulated during aging and diabetes, introducing changes in cell membrane physico-chemical and biological properties.

Keywords

• advanced glycation endproducts
• advanced lipoxidation endproducts
• age-associated diseases
• aging
• cell membrane
• carbonyl compounds
• lipid peroxidation
• Maillard reaction products
• oxidative stress
• phosphatidylethanolamine
• phosphatidylserine