Acta Medica Alanya (Nov 2018)
Clinical Evaluation of Our Cases with Prolactinoma
Abstract
Aim: In the present study, the treatment results and treatment methods of the patients who had aggressive-progressing prolactinoma in our clinic were evaluated retrospectively. The purpose was to identify the most appropriate follow-up and treatment strategies in similar cases.Patients and Methods: In this study of ours, the data recorded in our endocrinology clinic between 2004 and 2013 out of the patients, who were followed-up in our clinic with a multidisciplinary approach in Hypophysis Council, were examined retrospectively. The patients were classified as Remission with Medical Treatment, Remission with Surgery, Remission with Medical Treatment After Surgery, Drug Resistance, and Surgery and “Second Surgery after Tumor Progression after Medical Treatment.Results: A total of 65 patients were included in the study. A total of 61.5% (n=40) of the patients were female; and 38.4% (n=25) were male. All of the cases were divided into two as 60% with microadenomas and 40% with macroadenomas. 37 cases received medical treatment, 7 patients received surgery, and 17 patients received medical treatment after surgery. A total of 69.4% of the patients, who were followed up due to microadenoma, had remission with medical treatment; 8.3% had remission with surgical treatment; and 8.3% had remission with medical treatment after surgery. It was determined that 20% of the 25 patients, who were followed-up due to macroadenoma, had remission with medical treatment; 16% had remission with surgical treatment; and 48% had remission with medical treatment after surgery. The average resistance in the cases was 11.4%. Conclusion: Despite its benign nature, prolactinoma is a hypophysis tumor with difficult treatment. Although the medical treatment responses in our study were compatible with existing literature, the prevalence of the surgical operation in our study was found to be more when compared to existing literature. This situation may be explained with the fact that the patients with aggressive progression were included in the present study of ours.
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