Nature Communications (May 2016)
The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages
- Yunlong Yang,
- Patrik Andersson,
- Kayoko Hosaka,
- Yin Zhang,
- Renhai Cao,
- Hideki Iwamoto,
- Xiaojuan Yang,
- Masaki Nakamura,
- Jian Wang,
- Rujie Zhuang,
- Hiromasa Morikawa,
- Yuan Xue,
- Harald Braun,
- Rudi Beyaert,
- Nilesh Samani,
- Susumu Nakae,
- Emily Hams,
- Steen Dissing,
- Padraic G. Fallon,
- Robert Langer,
- Yihai Cao
Affiliations
- Yunlong Yang
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institute
- Patrik Andersson
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institute
- Kayoko Hosaka
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institute
- Yin Zhang
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institute
- Renhai Cao
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institute
- Hideki Iwamoto
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institute
- Xiaojuan Yang
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institute
- Masaki Nakamura
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institute
- Jian Wang
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institute
- Rujie Zhuang
- The TCM Hospital of Zhejiang Province
- Hiromasa Morikawa
- Department of Medicine, Unit of Computational Medicine, Center for Molecular Medicine, Karolinska Institute
- Yuan Xue
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institute
- Harald Braun
- Department of Biomedical Molecular Biology, Ghent University
- Rudi Beyaert
- Department of Biomedical Molecular Biology, Ghent University
- Nilesh Samani
- Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital
- Susumu Nakae
- Laboratory of Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo
- Emily Hams
- School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, College Green
- Steen Dissing
- Department of Cellular and Molecular Medicine, Panum Institute, University of Copenhagen
- Padraic G. Fallon
- School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, College Green
- Robert Langer
- Institute for Medical Engineering and Science, Massachusetts Institute of Technology
- Yihai Cao
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institute
- DOI
- https://doi.org/10.1038/ncomms11385
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 18
Abstract
Elevated IL-33 levels have been correlated with metastasis and poor prognosis. Here the authors show in mouse tumour xenograft models that PDGF-BB produced by tumour cells induces IL-33 via Sox7 in tumour pericytes, and IL-33 promotes metastasis through its effects on tumour-associated macrophages.
