Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains

Arianne Lovey; Sheetal Verma; Vaishnavi Kaipilyawar; Rodrigo Ribeiro-Rodrigues; Seema Husain; Moises Palaci; Reynaldo Dietze; Shuyi Ma; Robert D. Morrison; David. R. Sherman; Jerrold J. Ellner; Padmini Salgame

doi:10.1038/s41467-022-28506-2

Nature Communications (Feb 2022)

Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains

Arianne Lovey,
Sheetal Verma,
Vaishnavi Kaipilyawar,
Rodrigo Ribeiro-Rodrigues,
Seema Husain,
Moises Palaci,
Reynaldo Dietze,
Shuyi Ma,
Robert D. Morrison,
David. R. Sherman,
Jerrold J. Ellner,
Padmini Salgame

Affiliations

Arianne Lovey: Center for Emerging Pathogens, Department of Medicine, Rutgers-New Jersey Medical School
Sheetal Verma: Center for Emerging Pathogens, Department of Medicine, Rutgers-New Jersey Medical School
Vaishnavi Kaipilyawar: Center for Emerging Pathogens, Department of Medicine, Rutgers-New Jersey Medical School
Rodrigo Ribeiro-Rodrigues: Núcleo de Doenças Infecciosas, NDI/Universidade Federal do Espirito Santo-UFES
Seema Husain: The Genomics Center, Rutgers—New Jersey Medical School
Moises Palaci: Núcleo de Doenças Infecciosas, NDI/Universidade Federal do Espirito Santo-UFES
Reynaldo Dietze: Núcleo de Doenças Infecciosas, NDI/Universidade Federal do Espirito Santo-UFES
Shuyi Ma: Center for Global Infectious Disease Research, Seattle Children’s Research Institute
Robert D. Morrison: Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, NIH
David. R. Sherman: Department of Microbiology, University of Washington
Jerrold J. Ellner: Center for Emerging Pathogens, Department of Medicine, Rutgers-New Jersey Medical School
Padmini Salgame: Center for Emerging Pathogens, Department of Medicine, Rutgers-New Jersey Medical School

DOI: https://doi.org/10.1038/s41467-022-28506-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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Halting tuberculosis transmission is crucial to TB elimination. Here the authors implicate IL-1R dependent T cell priming as the underlying mechanism determining variability in transmission of Mycobacterium tuberculosis strains.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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