Nature Communications (Oct 2021)

Nuclear transporter Importin-13 plays a key role in the oxidative stress transcriptional response

  • K. A. Gajewska,
  • H. Lescesen,
  • M. Ramialison,
  • K. M. Wagstaff,
  • D. A. Jans

DOI
https://doi.org/10.1038/s41467-021-26125-x
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

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Importin superfamily member IPO13 mediates nuclear transport bidirectionally. Here the authors delineate the transcriptome of wild-type and IPO13-knockout mouse embryonic stem cells, revealing IPO13’s key role in the oxidative stress response through targeted transport of specific transcription factors.