Морфологія (Jan 2011)
Evaluation of pathomorphological changes and survival after selective intraarterial polychemotherapy of locally advanced breast cancer
Abstract
The pathomorphological changes (pathologic response) and survival of patients with locally advanced breastcancer (BC) were analyzed for the 89 patients treated with selective intraarterial polychemotherapy (PCT) in neoadjuvantmode and 46 treated with intravenous PCT in the same mode (control). More significant pathomorphological response afterthe treatment of BC in the neoadjuvant mode was achieved after selective intra-arterial PCT (p<0,01). In the intraarterial PCTgroup pathomorphosis grade 4 was observed in 16.9% (control – 8.70%), grade 3 – 37,0% (control – 28.3%), grade 2 –46,1% (control – 26,1%). In the control group 1 degree pathomorphosis was in 26.1% of patients, no pathologic response – in10,9%. In patients with pathomorphosis of 2-4 degrees in intraarterial PCT group 5-year survival increases by 0,90-5,60%compared with the control, 10-year-old survival – by 5,60-11,6%. Survival tended to increase with the degree of pathomorphosiswithout statistical differences in groups of intraarterial and intravenous PCT for each year of observation. The averagelife expectancy for the intraarterial PCT group was 4,61±0,02 years, for the control group – 4,19±0,05 (p<0,001). For 1-7years difference in survival was within 5,8-9,5%. The best results are observed after seventh year: 7-10-year survival inintraarterial PCT group was 38.2%, in the control group – 23,9%.
