Nature Communications (Dec 2018)

Spatial fine-mapping for gene-by-environment effects identifies risk hot spots for schizophrenia

  • Chun Chieh Fan,
  • John J. McGrath,
  • Vivek Appadurai,
  • Alfonso Buil,
  • Michael J. Gandal,
  • Andrew J. Schork,
  • Preben Bo Mortensen,
  • Esben Agerbo,
  • Sandy A. Geschwind,
  • Daniel Geschwind,
  • Thomas Werge,
  • Wesley K. Thompson,
  • Carsten Bøcker Pedersen

DOI
https://doi.org/10.1038/s41467-018-07708-7
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 7

Abstract

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Schizophrenia (SCZ) risk is influenced by genetic and environmental factors. Here, the authors develop a statistical method for analyzing gene-by-environment effects in SCZ risk across Denmark with fine spatial resolution.