THE LOCAL APPLICATION OF AUTHOLOGICAL MONONUCLEAR BLOOD CELLS FOR THE ENDOTHELIAN EPITHELIAN CORNEAL DYSTROPHY EXPERIMENTAL TREATMENT

Abstract

Aim. The article illustrates the way of endothelian – epithepial corneal dystrophy regeneration with intracameral using of authological mononuclear blood cells.Materials and methods. The series of experiments were made on Wistar rats. The main group of animals (12) was done intracameral injection the authological mononuclear blood cells on the posterior corneal surface after corneal dystrophy simulation. The control animals group (12) was made a tradition treatment.The results experiment has shown a high effect of mononuclear cells treatment. The number of dystrophy changed epithelial cells reduced in the main group on the third day after treatment start. The proliferation of endothelian was shown on the seventh day after the treatment in the main group. On the fourteenth day the corneal endothelian was restored in the main animals group. The corneal endothelian layer in the control group hasn’t restored on the twenty first day.Thus, intra cameral injection of authological mononuclear blood cells induces the regeneration of corneal endothelian layer in endothelian – epithepial corneal dystrophy treatment.

Keywords

• эндотелиально-эпителиальная дистрофия
• аутологичные мононуклеары крови
• полипотентность клеток
• микроокружение
• регенерация