Functions of PARylation in DNA Damage Repair Pathways

Genomics, Proteomics & Bioinformatics. 2016;14(3):131-139 DOI 10.1016/j.gpb.2016.05.001


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Journal Title: Genomics, Proteomics & Bioinformatics

ISSN: 1672-0229 (Print)

Publisher: Elsevier

Society/Institution: Beijing Institute of Genomics, Chinese Academy of Sciences and Genetics Society of China

LCC Subject Category: Science: Biology (General)

Country of publisher: China

Language of fulltext: English

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Huiting Wei (Department of Immunology, Tianjin Key Laboratory of Cellular and Molecular Immunology, MOE Key Laboratory of Immune Microenvironment and Disease, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China)

Xiaochun Yu (Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope Medical Center, Duarte, CA 91010, USA)


Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 23 weeks


Abstract | Full Text

Protein poly ADP-ribosylation (PARylation) is a widespread post-translational modification at DNA lesions, which is catalyzed by poly(ADP-ribose) polymerases (PARPs). This modification regulates a number of biological processes including chromatin reorganization, DNA damage response (DDR), transcriptional regulation, apoptosis, and mitosis. PARP1, functioning as a DNA damage sensor, can be activated by DNA lesions, forming PAR chains that serve as a docking platform for DNA repair factors with high biochemical complexity. Here, we highlight molecular insights into PARylation recognition, the expanding role of PARylation in DDR pathways, and the functional interaction between PARylation and ubiquitination, which will offer us a better understanding of the biological roles of this unique post-translational modification.